Thanks Dunadan. The first 3 all are using the existing Penalty effect. It might be worthwhile to put those types of effects in a separate module for people to use. The onees JohnD mentioned would allow effecting specific rolls instead of all rolls like the Penalty effect.
The Con damage can be track directly on the Main tab now but I could see using stat effects for more temporary things.
The critical one would be a bit tough at the moment but I do plan on trying to do something similar for the NPCs so the critical severity reduction or use of large/super large critical tables is more automated. After that the critical effects should be possible.
The chance to miss might be possible with a separate roll for it but I would want it to still go to the Table Resolver just in case there is an issue so the GM could still resolve it. Then I would need to make it obvious to the GM that it actually missed.
Once I add effects to the character sheet (spells tab initially) then the players should be able to apply effects like in other rulesets. I will need to test a few ideas that I have where a player might be able to do it now but I won't be sure until I try it out when I get a chance.